CD273 Recombinant Protein

• Background :

  Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

• NCBI Gene ID :

  80380

• Swiss Prot :

  Q9BQ51

• Accession Number :

  AAI13679

• Tag :

  C-Fc Tag

• Type :

  Recombinant Proteins

• Source :

  HEK293 cells

• Field of Research :

  Apoptosis, Immunology

• Purity :

  >95% as determined by SDS-PAGE more than 90% measured by SEC-HPLC.

• Buffer :

  PBS, pH7.4

• Shipping Conditions :

  Room Temp

• Storage Conditions :

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight :

  49.2 kDa

• Applications Notes :

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name :

  Programmed cell death 1 ligand 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846.

• Background Reference 02 :

  Latchman Y., et al., 2001, Nat. Immunol. 2:261-268.

• Background Reference 03 :

  He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.

• Other Product Names :

  PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2

• Tested Applications :

  WB

• Species :

  Human

• Physical Properties :

  Lyophilized

• CAS Number :

  9000-83-3