CD273 [PD-L2] non-lytic Recombinant Protein

• Background:

  T cells require a signal induced by the engagement of the T cell receptor and a €œcostimulatory€ signal (s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.

• NCBI Gene ID:

  80380

• Swiss Prot:

  P05112

• Accession Number:

  NP_079515

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Apoptosis, Immunology

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Programmed cell death 1 ligand 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PD-L2, Programmed Cell Death 1 Ligand 2, PDCD1 Ligand 2, B7-DC, PDL2

• Species:

  Human

• Protein ID:

  190014605

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3