CD276 Antibody

• Background:

  CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1) . CD276 mRNA is widely expressed, but its protein expression is usually rather low (2) . CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3) . In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4) . It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.

• NCBI Gene ID:

  80381

• Swiss Prot:

  Q5ZPR3

• Accession Number:

  NP_001019907

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Cancer, Immunology

• Purification:

  CD276 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  CD276 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CD276 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least three antibodies are known to exist; this antibody will detect all three isoforms.

• Symbol:

  CD276

• Positive Control 2:

  Cat. No. 1406 - Mouse Spleen Tissue Lysate

• NCBI Official Name:

  CD276 molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.

• Background Reference 02:

  Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.

• Background Reference 03:

  Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.

• Background Reference 04:

  Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71.

• Other Product Names:

  CD276 Antibody: CD276 molecule, B7H3, B7-H3, B7RP-2, 4Ig-B7-H3

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  67188443

• Physical Properties:

  Liquid