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CD276 Antibody

CAT: 0223-8689-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8689-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1) . CD276 mRNA is widely expressed, but its protein expression is usually rather low (2) . CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3) . In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4) . It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
NCBI Gene ID
80381
Swiss Prot
Q5ZPR3
Accession Number
NP_001019907
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Immunology
Purification
CD276 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
CD276 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CD276 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three antibodies are known to exist; this antibody will detect all three isoforms.
Symbol
CD276
Positive Control 2
Cat. No. 1406 - Mouse Spleen Tissue Lysate
NCBI Official Name
CD276 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.
Background Reference 02
Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.
Background Reference 03
Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.
Background Reference 04
Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71.
Other Product Names
CD276 Antibody: CD276 molecule, B7H3, B7-H3, B7RP-2, 4Ig-B7-H3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
67188443
Physical Properties
Liquid

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