ZAP70 Antibody [3D2A4]

• Background:

  ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Zap70 controls TCR (T-cell antigen receptor) -linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the zap-70 gene. ZAP-70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

• NCBI Gene ID:

  7535

• Swiss Prot:

  P43403

• Accession Number:

  P43403

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified truncated recombinant ZAP70 expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  3D2A4

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Immunology, Innate Immunity

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZAP70 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  ZAP70

• NCBI Official Name:

  Zeta-chain (TCR) associated protein kinase 70kDa

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sigal Gelkop , Gerrald D. Gish, Yael Babichev J Immunol. 2005 Dec 15;175 (12) :8123-32.

• Background Reference 02:

  Joaquim Carreras , Neus Villamor , Lluis Colomo J Pathol. 2005 Mar;205 (4) :507-13.

• Background Reference 03:

  Claire Hivroz Med Sci (Paris) . 2005 Feb;21 (2) :150-5.

• Other Product Names:

  SRK, 70 kDa zeta-chain associated proteinSRK, STD, TZK, STCD, ZAP-70

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  1177044