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ZAP70 Antibody

CAT: 0223-57-509Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-509Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
NCBI Gene ID
7535
Swiss Prot
P43403
Accession Number
P43403
Host
Rabbit
Reactivity
Human
Immunogen
This ZAP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from the N-terminal region of human ZAP70.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Symbol
ZAP70
NCBI Official Name
Tyrosine-protein kinase ZAP-70
NCBI Organism
Homo sapiens
Background Reference 01
Zanotti, R., et al. Am. J. Hematol. 85 (7) :494-498 (2010)
Background Reference 02
Lin, Y.P., et al. Mol. Immunol. 47 (11-12), 2022-2029 (2010) :
Background Reference 03
Liu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (22) :10166-10171 (2010)
Background Reference 04
Kotaskova, J., et al.Mol Diagn 12 (3) :328-334 (2010)
Other Product Names
Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
Tested Applications
WB, IHC-P
Protein ID
1177044
Physical Properties
Liquid

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