DDR2 Antibody [3B11E4]

• Background:

  DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

• NCBI Gene ID:

  4921

• Swiss Prot:

  Q16832

• Accession Number:

  Q16832

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified truncated recombinant DDR2-Trx expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  3B11E4

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  DDR2 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG2a

• Symbol:

  DDR2

• NCBI Official Name:

  Discoidin domain receptor tyrosine kinase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leitinger B. Kwan AP. Matrix Biol. 2006, Aug, 25 (6) :355-64. Epub 2006 May 26.

• Background Reference 02:

  Shyu KG. Chao YM. Wang BW. et al. Hypertension. 2005, Sep, 46 (3) :614-21. Epub 2005 Aug 8.

• Background Reference 03:

  Neale JC. Kenny TP. Gershwin ME. Clin Dev Immunol. 2004, Jun, 11 (2) :157-63.

• Other Product Names:

  NTRKR3, TKT, TYRO10, CD167 antigen-like family member B, Discoidin domain receptor 2, MIG20a, NTRKR3

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  215273969