DDR2 Antibody

• Background:

  Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

• NCBI Gene ID:

  4921

• Swiss Prot:

  Q16832

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_001014796.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 110kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  DDR2

• Positive Control 2:

  A375

• Positive Control 3:

  HT-1080

• Positive Control 4:

  Mouse lung

• Positive Control 5:

  Mouse heart

• Positive Control 6:

  Mouse kidney

• NCBI Official Name:

  Discoidin domain receptor tyrosine kinase 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DDR2, CD167b antigen, Discoidin domain receptor 2, Hydroxyaryl-protein kinase, MIG20a, Tyrosine-protein kinase TYRO10, NTRKR3, TYRO10, Tyrosylprotein kinase

• Tested Applications:

  WB

• Physical Properties:

  Liquid