DDR2 Antibody

• Background:

  Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane and cytoplasmic regions. There are several subclasses of RTKs and TYRO10 belongs to a novel subclass. The deduced amino acid sequence of TYRO10 has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs.

• NCBI Gene ID:

  4921

• Swiss Prot:

  Q16832

• Accession Number:

  Q16832

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DDR2 (TYRO10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2 (TYRO10) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  97 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DDR2

• NCBI Official Name:

  Discoidin domain-containing receptor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vogel, W., et al., Mol. Cell 1 (1) :13-23 (1997) .

• Background Reference 02:

  Edelhoff, S., et al., Genomics 25 (1) :309-311 (1995) .

• Background Reference 03:

  Karn, T., et al., Oncogene 8 (12) :3433-3440 (1993) .

• Background Reference 04:

  Abedinia, M., et al., Biochem. Biophys. Res. Commun. 183 (3) :1159-1166 (1992) .

• Other Product Names:

  Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10

• Tested Applications:

  WB

• Protein ID:

  215273969

• Physical Properties:

  Liquid