AMACR Antibody [2A10F3]

• Background:

  AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) ; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.

• NCBI Gene ID:

  23600

• Swiss Prot:

  Q9UHK6

• Accession Number:

  Q9UHK6

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified truncated recombinant AMACR-His fusion protein expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  2A10F3

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Neuroscience

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  AMACR monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG2b

• Symbol:

  AMACR

• NCBI Official Name:

  Alpha-methylacyl-CoA racemase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen Q. Watson JT. Marengo SR. et al. Cancer Lett. 2006, Dec 8, 244 (2) :274-88.Epub 2006 Feb 23.

• Background Reference 02:

  Epstein JI. Herawi M. J Urol. 2006, Mar, 175 (3 Pt 1) :820-34. Review.

• Other Product Names:

  2-methylacyl-CoA racemaseRM, RACE, CBAS4, AMACRD

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  313104070