AMACR Antibody

• Background:

  This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.

• NCBI Gene ID:

  23600

• Swiss Prot:

  Q9UHK6

• Accession Number:

  Q9UHK6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AMACR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the C-terminal region of human AMACR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  AMACR

• NCBI Official Name:

  Alpha-methylacyl-CoA racemase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Murray, N.P., et al. Oncol. Rep. 24 (3) :687-692 (2010) Sonwalkar, S.A., et al. Histopathology 56 (7) :900-907 (2010) Lakis, S., et al. World J. Gastroenterol. 16 (20) :2476-2483 (2010) Chen, W., et al. Mol. Biol. Rep. 36 (3) :423-430 (2009) Mubiru, J.N., et al. Gene 327 (1) :89-98 (2004)

• Other Product Names:

  Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase, AMACR

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  313104070

• Physical Properties:

  Liquid