TAF2 Antibody

• Background:

  Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.

• NCBI Gene ID:

  6873

• Swiss Prot:

  Q6P1X5

• Accession Number:

  Q6P1X5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1152-1180 amino acids from the C-terminal region of human TAF2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  137 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TAF2

• NCBI Official Name:

  Transcription initiation factor TFIID subunit 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 02:

  Kim, J.E., et al. J. Proteome Res. 4 (4) :1339-1346 (2005)

• Background Reference 03:

  Guermah, M., et al. Mol. Cell 12 (4) :991-1001 (2003)

• Other Product Names:

  Transcription initiation factor TFIID subunit 2, 150 kDa cofactor of initiator function, RNA polymerase II TBP-associated factor subunit B, TBP-associated factor 150 kDa, Transcription initiation factor TFIID 150 kDa subunit, TAF (II) 150, TAFII-150, TAFII150, TAF2, CIF150, TAF2B

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  145559533

• Physical Properties:

  Liquid