CACNA2D3 Antibody

• Background :

  CACNA2D3 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.

• NCBI Gene ID :

  55799

• Swiss Prot :

  Q8IZS8

• Accession Number :

  Q8IZS8

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CACNA2D3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1026-1053 amino acids from the C-terminal region of human CACNA2D3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  123 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CACNA2D3

• NCBI Official Name :

  Voltage-dependent calcium channel subunit alpha-2/delta-3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

• Background Reference 02 :

  Wanajo, A., et al. Gastroenterology 135 (2) :580-590 (2008)

• Background Reference 03 :

  Uhl, G.R., et al. Arch. Gen. Psychiatry 65 (6) :683-693 (2008)

• Background Reference 04 :

  Abo-Dalo, B., et al. Am. J. Med. Genet.143A (22), 2668-2674 (2007)

• Other Product Names :

  Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3, Voltage-dependent calcium channel subunit alpha-2-3, Voltage-dependent calcium channel subunit delta-3, CACNA2D3

• Tested Applications :

  WB, Flow

• Protein ID :

  74723683

• Physical Properties :

  Liquid