CACNA2D2 Antibody

• Background :

  This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

• NCBI Gene ID :

  9254

• Swiss Prot :

  Q9NY47

• Accession Number :

  Q9NY47

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This CACNA2D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-671 amino acids from the Central region of human CACNA2D2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  130 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CACNA2D2

• NCBI Official Name :

  Voltage-dependent calcium channel subunit alpha-2/delta-2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Donato, R., et al. J. Neurosci. 26 (48) :12576-12586 (2006) Ivanov, S.V., et al. Am. J. Pathol. 165 (3) :1007-1018 (2004) Carboni, G.L., et al. Oncogene 22 (4) :615-626 (2003) Honorio, S., et al. Mol. Cell. Probes 15 (6) :391-393 (2001) Angeloni, D., et al. Mol. Cell. Probes 15 (2) :125-127 (2001)

• Other Product Names :

  Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558

• Tested Applications :

  WB, IHC-P, IF

• Protein ID :

  387912827

• Physical Properties :

  Liquid