CACNA2D4 Antibody

• Background:

  CACNA2D4 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

• NCBI Gene ID:

  93589

• Swiss Prot:

  Q7Z3S7

• Accession Number:

  Q7Z3S7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CACNA2D4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the N-terminal region of human CACNA2D4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  128 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CACNA2D4

• NCBI Official Name:

  Voltage-dependent calcium channel subunit alpha-2/delta-4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wycisk, K.A., et al. Am. J. Hum. Genet. 79 (5) :973-977 (2006)

• Background Reference 02:

  Qin, N., et al. Mol. Pharmacol. 62 (3) :485-496 (2002)

• Other Product Names:

  Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4, Voltage-dependent calcium channel subunit alpha-2-4, Voltage-dependent calcium channel subunit delta-4, CACNA2D4

• Tested Applications:

  WB, Flow

• Protein ID:

  296434419

• Physical Properties:

  Liquid