DKK1 Antibody

• Background:

  DKK1 is a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

• NCBI Gene ID:

  22943

• Swiss Prot:

  O94907

• Accession Number:

  O94907

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DKK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-84 amino acids from the N-terminal region of human DKK1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DKK1

• NCBI Official Name:

  Dickkopf-related protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Piters, E., et al. Calcif. Tissue Int. 86 (4) :271-281 (2010)

• Background Reference 02:

  Bourhis, E., et al. J. Biol. Chem. 285 (12) :9172-9179 (2010)

• Other Product Names:

  Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1

• Tested Applications:

  WB

• Physical Properties:

  Liquid