DKK3 Antibody

CAT: 0223-58-169Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-169Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
NCBI Gene ID
27122
Swiss Prot
Q9UBP4
Accession Number
Q9UBP4
Host
Rabbit
Reactivity
Human
Immunogen
This DKK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human DKK3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Symbol
DKK3
NCBI Official Name
Dickkopf-related protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) .
Background Reference 02
Tsuji, T., et al., Biochem. Biophys. Res. Commun. 268 (1) :20-24 (2000) .
Background Reference 03
Krupnik, V.E., et al., Gene 238 (2) :301-313 (1999) .
Background Reference 04
Kobayashi, K., et al., Gene 282 (1-2), 151-158 (2002) .
Other Product Names
Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC
Tested Applications
WB, IHC-P
Protein ID
311033372
Physical Properties
Liquid

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