DKK3 Antibody

• Background:

  DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.

• NCBI Gene ID:

  27122

• Swiss Prot:

  Q9UBP4

• Accession Number:

  Q9UBP4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DKK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human DKK3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  38 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DKK3

• NCBI Official Name:

  Dickkopf-related protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) .

• Background Reference 02:

  Tsuji, T., et al., Biochem. Biophys. Res. Commun. 268 (1) :20-24 (2000) .

• Background Reference 03:

  Krupnik, V.E., et al., Gene 238 (2) :301-313 (1999) .

• Background Reference 04:

  Kobayashi, K., et al., Gene 282 (1-2), 151-158 (2002) .

• Other Product Names:

  Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC

• Tested Applications:

  WB, IHC-P

• Protein ID:

  311033372

• Physical Properties:

  Liquid