DKK2 Antibody

CAT: 0223-58-167Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-167Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.
NCBI Gene ID
27123
Swiss Prot
Q9UBU2
Accession Number
Q9UBU2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DKK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-62 amino acids from the N-terminal region of human DKK2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Symbol
DKK2
NCBI Official Name
Dickkopf-related protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) . Brott, B.K., et al., Mol. Cell. Biol. 22 (17) :6100-6110 (2002) . Krupnik, V.E., et al., Gene 238 (2) :301-313 (1999) .
Other Product Names
Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2
Tested Applications
WB, IHC-P
Protein ID
13124093
Physical Properties
Liquid

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