Products for Research Use Only
RegisterLogin

DIO3 Antibody

CAT: 0223-63-991Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-63-991Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
NCBI Gene ID
1735
Swiss Prot
P55073
Accession Number
P55073
Host
Rabbit
Reactivity
Human
Immunogen
This DIO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Symbol
DIO3
NCBI Official Name
Type III iodothyronine deiodinase
NCBI Organism
Homo sapiens
Background Reference 01
Bessho, K., et al. Eur. J. Pediatr. 169 (2) :215-221 (2010)
Background Reference 02
Wallace, C., et al. Nat. Genet. 42 (1) :68-71 (2010)
Background Reference 03
Aerts, G., et al. Endocrinology 150 (11) :5171-5180 (2009)
Background Reference 04
Panicker, V., et al. J. Clin. Endocrinol. Metab. 94 (5) :1623-1629 (2009)
Other Product Names
Type III iodothyronine deiodinase, 5DIII, DIOIII, Type 3 DI, Type-III 5'-deiodinase, DIO3, ITDI3, TXDI3
Tested Applications
WB, IHC-P
Protein ID
172045679
Physical Properties
Liquid

Related Products

CatalogName
62-559DIO1 Antibody
46-651DIO2 Antibody
63-610DIO2 Antibody
46-651PDIO2 Peptide
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody

Alternative Products

CatalogName
MBS7052681-01DIO3 Antibody

Popular Products