DIO1 Antibody

• Background:

  DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3) . It also degrades both hormones by inner ring deiodination (IRD) .

• NCBI Gene ID:

  1733

• Swiss Prot:

  P49895

• Accession Number:

  P49895

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DIO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-57 amino acids from the N-terminal region of human DIO1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DIO1

• NCBI Official Name:

  Type I iodothyronine deiodinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Landa, I., et.al., PLoS Genet. (9), E1000637 (2009)

• Other Product Names:

  Type I iodothyronine deiodinase, 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase, DIO1, ITDI1, TXDI1

• Tested Applications:

  WB

• Protein ID:

  182702125

• Physical Properties:

  Liquid