DIO2 Antibody

• Background:

  DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3) .

• NCBI Gene ID:

  1734

• Swiss Prot:

  Q92813

• Accession Number:

  Q92813

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DIO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the Central region of human DIO2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DIO2

• NCBI Official Name:

  Type II iodothyronine deiodinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  He, B., et.al., Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (6), 986-990 (2009)

• Background Reference 02:

  Heemstra, K.A., et.al., J. Clin. Endocrinol. Metab. 94 (6), 2144-2150 (2009)

• Other Product Names:

  Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  172045839

• Physical Properties:

  Liquid