PTPH1 Antibody

Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.

5774

P26045

P26045

Human, Mouse

This PTPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-397 amino acids from the Central region of human PTPH1.

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

104 kDa

Rabbit Ig

PTPN3

Tyrosine-protein phosphatase non-receptor type 3

Homo sapiens

Ikuta, S., et al., J. Gastroenterol. 29 (6) :727-732 (1994) .

Arimura, Y., et al., Tumour Biol. 13 (3) :180-186 (1992) .

Yang, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 88 (14) :5949-5953 (1991) .

Tyrosine-protein phosphatase non-receptor type 3, Protein-tyrosine phosphatase H1, PTP-H1, PTPN3, PTPH1

WB, IHC-P

229462761