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PTPD1 Antibody

CAT: 0223-63-463Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-463Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
NCBI Gene ID
11099
Swiss Prot
Q16825
Accession Number
Q16825
Host
Rabbit
Reactivity
Human
Immunogen
This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
133 kDa
Fragment
Rabbit Ig
Symbol
PTPN21
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 21
NCBI Organism
Homo sapiens
Background Reference 01
Jui, H.Y., et al., J. Biol. Chem. 275 (52) :41124-41132 (2000) .
Background Reference 02
Tokuchi, H., et al., IntUrol 6 (11) :572-577 (1999) .
Background Reference 03
Higashitsuji, H., et al., Oncogene 10 (2) :407-414 (1995) .
Background Reference 04
Moller, N.P., et al., Proc. Natl. Acad. Sci. U.S.A. 91 (16) :7477-7481 (1994) .
Other Product Names
Tyrosine-protein phosphatase non-receptor type 21, Protein-tyrosine phosphatase D1, PTPN21, PTPD1
Tested Applications
WB, IHC-P
Protein ID
290457654
Physical Properties
Liquid

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