GNB2L1 Antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K) . MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

10399

P63244

P63244

Human

This GNB2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human GNB2L1.

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Batch dependent

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Monkey, Mouse, Pig, Rat

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

35 kDa

Rabbit Ig

GNB2L1

Guanine nucleotide-binding protein subunit beta-2-like 1

Homo sapiens

Ceci, M., et al., Nature 426 (6966) :579-584 (2003) .

Usacheva, A., et al., J. Immunol. 171 (6) :2989-2994 (2003) .

Kiely, P.A., et al., J. Biol. Chem. 277 (25) :22581-22589 (2002) .

Tcherkasowa, A.E., et al., J. Immunol. 169 (9) :5161-5170 (2002) .

Guanine nucleotide-binding protein subunit beta-2-like 1, Cell proliferation-inducing gene 21 protein, Guanine nucleotide-binding protein subunit beta-like protein 123, Human lung cancer oncogene 7 protein, HLC-7, Receptor for activated C kinase, Receptor of activated protein kinase C 1, RACK1, Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed, GNB2L1

WB, IHC-P

54037168