ARH Antibody

• Background:

  LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts) . LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

• NCBI Gene ID:

  26119

• Swiss Prot:

  Q5SW96

• Accession Number:

  Q5SW96

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARH (LDLRAP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the C-terminal region of human ARH (LDLRAP1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  LDLRAP1

• NCBI Official Name:

  Low density lipoprotein receptor adapter protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Maurer, M.E., J. Cell. Sci. 119 (PT 20), 4235-4246 (2006)

• Background Reference 02:

  Keyel, P.A., Mol. Biol. Cell 17 (10), 4300-4317 (2006)

• Other Product Names:

  Low density lipoprotein receptor adapter protein 1, Autosomal recessive hypercholesterolemia protein, LDLRAP1, ARH

• Tested Applications:

  WB, IHC-P

• Protein ID:

  116241254

• Physical Properties:

  Liquid