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ARHB Antibody

CAT: 0223-56-309Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-309Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
NCBI Gene ID
388
Swiss Prot
P62745
Accession Number
P62745
Host
Rabbit
Reactivity
Human
Immunogen
This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-137 amino acids from the Central region of human ARHB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Symbol
RHOB
NCBI Official Name
Rho-related GTP-binding protein RhoB
NCBI Organism
Homo sapiens
Background Reference 01
Adly, M.A., et al. J. Cutan. Pathol. 37 (7) :751-757 (2010)
Background Reference 02
Connolly, E.C., et al. Mol. Cancer Res. 8 (5) :691-700 (2010)
Background Reference 03
Zintzaras, E., et al. Am. J. Epidemiol. 171 (8) :851-858 (2010)
Background Reference 04
Kim, C.H., et al. Biochem. Biophys. Res. Commun. 391 (2) :1182-1186 (2010)
Other Product Names
Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB
Tested Applications
WB, IHC-P
Protein ID
51338601
Physical Properties
Liquid

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