ARHB Antibody

• Background:

  ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.

• NCBI Gene ID:

  388

• Swiss Prot:

  P62745

• Accession Number:

  P62745

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-137 amino acids from the Central region of human ARHB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RHOB

• NCBI Official Name:

  Rho-related GTP-binding protein RhoB

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Adly, M.A., et al. J. Cutan. Pathol. 37 (7) :751-757 (2010)

• Background Reference 02:

  Connolly, E.C., et al. Mol. Cancer Res. 8 (5) :691-700 (2010)

• Background Reference 03:

  Zintzaras, E., et al. Am. J. Epidemiol. 171 (8) :851-858 (2010)

• Background Reference 04:

  Kim, C.H., et al. Biochem. Biophys. Res. Commun. 391 (2) :1182-1186 (2010)

• Other Product Names:

  Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB

• Tested Applications:

  WB, IHC-P

• Protein ID:

  51338601

• Physical Properties:

  Liquid