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ARHE Antibody

CAT: 0223-63-181Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-181Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925) ; GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855) ; and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998 [PubMed 9531558]) .
NCBI Gene ID
390
Swiss Prot
P61587
Accession Number
P61587
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This ARHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 amino acids from the Central region of human ARHE.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Symbol
RND3
NCBI Official Name
Rho-related GTP-binding protein RhoE
NCBI Organism
Homo sapiens
Background Reference 01
Pinner, S., Nat. Cell Biol. 10 (2), 127-137 (2008)
Background Reference 02
Poch, E., Exp. Cell Res. 313 (4), 719-731 (2007)
Background Reference 03
Ongusaha, P.P., Curr. Biol. 16 (24), 2466-2472 (2006)
Other Product Names
Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3, RND3, ARHE, RHO8, RHOE
Tested Applications
WB, IHC-P
Protein ID
47606459
Physical Properties
Liquid

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