PIM2 Antibody

• Background:

  Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases. Pim-2 is highly homologous to Pim-1 with similar oncogenic functions. Pim-2 overexpression promotes resistance to a host of apoptotic stimuli; its expression is negatively regulated by growth factor depletion. Increased levels of Pim-2 has also been observed in certain cancers.

• NCBI Gene ID:

  11040

• Swiss Prot:

  Q9P1W9

• Accession Number:

  Q9P1W9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-308 amino acids from the C-terminal region of human PIM2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PIM2

• NCBI Official Name:

  Serine/threonine-protein kinase pim-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yan, B., et al., J. Biol. Chem. 278 (46) :45358-45367 (2003) .

• Background Reference 02:

  Baytel, D., et al., Biochim. Biophys. Acta 1442 (2-3), 274-285 (1998) .

• Other Product Names:

  Serine/threonine-protein kinase pim-2, Pim-2h, PIM2

• Tested Applications:

  WB, IHC-P, IP

• Protein ID:

  20139243

• Physical Properties:

  Liquid