PIM1 Antibody

• Background:

  PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.

• NCBI Gene ID:

  5292

• Swiss Prot:

  P11309

• Accession Number:

  P11309

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-404 amino acids from the C-terminal region of human PIM1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein G column, followed by dialysis against PBS.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PIM1

• NCBI Official Name:

  Serine/threonine-protein kinase pim-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) . Pasqualucci, L., et al., Nature 412 (6844) :341-346 (2001) . Koike, N., et al., FEBS Lett. 467 (1) :17-21 (2000) . Reeves, R., et al., Gene 90 (2) :303-307 (1990) . Telerman, A., et al., Mol. Cell. Biol. 8 (4) :1498-1503 (1988) .

• Other Product Names:

  Serine/threonine-protein kinase pim-1, PIM1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  83305339

• Physical Properties:

  Liquid