MEK1 / 2 Antibody

• Background:

  Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

• NCBI Gene ID:

  5604

• Swiss Prot:

  Q02750

• Accession Number:

  NP_002746.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  MEK1/2 antibody was raised against a peptide sequence around aa.235-239 (L-Q-G-T-H) derived from Human MEK1/2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  45 kDa

• Specificity:

  This antibody detects endogenous level of total MEK1/2 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  MAP2K1

• NCBI Official Name:

  Mitogen-activated protein kinase kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Seger R., Seger D., Lozeman F. J., Ahn N. G., Graves L. M., Campbell J. S., Ericsson L., Harrylock M., Jensen A. M., Krebs E. G. J. Biol. Chem. 267:25628-25631 (1992) Mukherjee S., Keitany G., Li Y., Wang Y., Ball H. L., Goldsmith E. J., Orth K. Science 312:1211-1214 (2006)

• Other Product Names:

  CFC3, MEK1, MKK1, MAPKK1, PRKMK1

• Tested Applications:

  WB

• Protein ID:

  5579478

• Physical Properties:

  Liquid