DDR1 Antibody

• Background:

  Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI) . In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.

• NCBI Gene ID:

  780

• Swiss Prot:

  Q08345

• Accession Number:

  Q08345

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human DDR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DDR1

• NCBI Official Name:

  Epithelial discoidin domain-containing receptor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vogel, W., et al., Mol. Cell 1 (1) :13-23 (1997) . Playford, M.P., et al., Genome Res. 6 (7) :620-627 (1996) . Perez, J.L., et al., Oncogene 12 (7) :1469-1477 (1996) . Valent, A., et al., Hum. Genet. 98 (1) :12-15 (1996) . Edelhoff, S., et al., Genomics 25 (1) :309-311 (1995) .

• Other Product Names:

  Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, CD167a, DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  729008

• Physical Properties:

  Liquid