MAPK15 Antibody

• Background :

  The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.

• NCBI Gene ID :

  225689

• Swiss Prot :

  Q8TD08

• Accession Number :

  Q8TD08

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MAPK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  60 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MAPK15

• NCBI Official Name :

  Mitogen-activated protein kinase 15

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Saelzler, M.P., J. Biol. Chem. 281 (24), 16821-16832 (2006)

• Background Reference 02 :

  Iavarone, C., J. Biol. Chem. 281 (15), 10567-10576 (2006)

• Background Reference 03 :

  Klevernic, I.V., Biochem. J. 394 (PT 1), 365-373 (2006)

• Background Reference 04 :

  Suzuki, Y., Genome Res. 14 (9), 1711-1718 (2004)

• Other Product Names :

  Mitogen-activated protein kinase 15, MAP kinase 15, MAPK 15, Extracellular signal-regulated kinase 7, ERK-7, Extracellular signal-regulated kinase 8, ERK-8, MAPK15, ERK7, ERK8

• Tested Applications :

  WB, IHC-P

• Protein ID :

  74760462

• Physical Properties :

  Liquid