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MAPK15 Antibody

CAT: 0223-62-984Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-984Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
NCBI Gene ID
225689
Swiss Prot
Q8TD08
Accession Number
Q8TD08
Host
Rabbit
Reactivity
Human
Immunogen
This MAPK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
MAPK15
NCBI Official Name
Mitogen-activated protein kinase 15
NCBI Organism
Homo sapiens
Background Reference 01
Saelzler, M.P., J. Biol. Chem. 281 (24), 16821-16832 (2006)
Background Reference 02
Iavarone, C., J. Biol. Chem. 281 (15), 10567-10576 (2006)
Background Reference 03
Klevernic, I.V., Biochem. J. 394 (PT 1), 365-373 (2006)
Background Reference 04
Suzuki, Y., Genome Res. 14 (9), 1711-1718 (2004)
Other Product Names
Mitogen-activated protein kinase 15, MAP kinase 15, MAPK 15, Extracellular signal-regulated kinase 7, ERK-7, Extracellular signal-regulated kinase 8, ERK-8, MAPK15, ERK7, ERK8
Tested Applications
WB, IHC-P
Protein ID
74760462
Physical Properties
Liquid

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