DYRK1B Antibody

• Background:

  DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.

• NCBI Gene ID:

  9149

• Swiss Prot:

  Q9Y463

• Accession Number:

  Q9Y463

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the C-terminal region of human DYRK1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  69 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DYRK1B

• NCBI Official Name:

  Dual specificity tyrosine-phosphorylation-regulated kinase 1B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lim, S., et al., J. Biol. Chem. 277 (51) :49438-49445 (2002) .

• Background Reference 02:

  Lim, S., et al., J. Biol. Chem. 277 (28) :25040-25046 (2002) .

• Background Reference 03:

  Lee, K., et al., Cancer Res. 60 (13) :3631-3637 (2000) .

• Background Reference 04:

  Leder, S., et al., Biochem. Biophys. Res. Commun. 254 (2) :474-479 (1999) .

• Other Product Names:

  Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Minibrain-related kinase, Mirk protein kinase, DYRK1B, MIRK

• Tested Applications:

  WB, IHC-P

• Protein ID:

  9296963

• Physical Properties:

  Liquid