DYRK1B Antibody

• Background:

  DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq].

• NCBI Gene ID:

  9149

• Swiss Prot:

  Q9Y463

• Accession Number:

  Q9Y463

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-405 amino acids from the Central region of human DYRK1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  69 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DYRK1B

• NCBI Official Name:

  Dual specificity tyrosine-phosphorylation-regulated kinase 1B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lauth, M., et al. Nat. Struct. Mol. Biol. 17 (6) :718-725 (2010)

• Background Reference 02:

  Yang, C., et al. Carcinogenesis 31 (4) :552-558 (2010)

• Background Reference 03:

  Jin, K., et al. J. Biol. Chem. 284 (34) :22916-22925 (2009)

• Background Reference 04:

  Deng, X., et al. Cancer Res. 69 (8) :3317-3324 (2009)

• Other Product Names:

  Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Minibrain-related kinase, Mirk protein kinase, DYRK1B, MIRK

• Tested Applications:

  WB

• Protein ID:

  9296963

• Physical Properties:

  Liquid