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DYRK1B antibody

CAT: 0710-FNab02592Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02592Size:100 µg
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Background
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC) .
Synonyms
Dual specificity tyrosine-phosphorylation-regulated kinase 1B|Minibrain-related kinase|Mirk protein kinase|DYRK1B|MIRK
Gene ID
9149
UniProt
Q9Y463
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 1B
Target
DYRK1B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q9Y463

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

DYR1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y463
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DYRK1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.12.1
Processing
—
Secondary accessions
O75258, O75788, O75789
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

ChromosomeNucleus

Disease

Diabetes mellitusObesity

Biological process

DNA damageDNA repair

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

PTM

Phosphoprotein

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