CDK4 Antibody

CAT: 0223-62-965Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-965Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.
NCBI Gene ID
1019
Swiss Prot
P11802
Accession Number
P11802
Host
Rabbit
Reactivity
Human
Immunogen
This CDK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human CDK4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Symbol
CDK4
NCBI Official Name
Cyclin-dependent kinase 4
NCBI Organism
Homo sapiens
Background Reference 01
Mori, N., et al., Int. J. Hematol. 77 (3) :259-262 (2003) .
Background Reference 02
Masaki, T., et al., Hepatology 37 (3) :534-543 (2003) .
Background Reference 03
Gump, J., et al., J. Biol. Chem. 278 (9) :6619-6622 (2003) .
Background Reference 04
Ramirez, R.D., et al., Oncogene 22 (3) :433-444 (2003) .
Other Product Names
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
1168867
Physical Properties
Liquid

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