CDK5 Antibody

• Background:

  This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  1020

• Swiss Prot:

  Q00535

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CDK5 (NP_004926.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Neuroscience, Obesity, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 30kDa

• Fragment:

  IgG

• Symbol:

  CDK5

• Positive Control 2:

  HepG2

• Positive Control 3:

  BT-474

• Positive Control 4:

  Mouse brain

• Positive Control 5:

  PC-12

• Positive Control 6:

  Rat brain

• NCBI Official Name:

  Cyclin-dependent kinase 5

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CDK5, PSSALRE

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid