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CDK7 Antibody

CAT: 0223-31-031Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-31-031Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Cdk7 is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
NCBI Gene ID
1022
Swiss Prot
P50613
Accession Number
NP_001790
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CDK7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cell Cycle, Cancer, Signal Transduction
Purification
Antibody is purified by Protein A/G affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CDK7 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
39 kDa
Applications Notes
CDK7 antibody can be used for detection of CDK7 by ELISA at 1:75000. CDK7 antibody can be used for detection of CDK7 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
CDK7
NCBI Official Name
Cyclin-dependent kinase 7
NCBI Organism
Homo sapiens
Background Reference 01
Tassan, J.P., et al., (1994) J. Cell Biol. 127:467-478..
Other Product Names
CDK7, CAK1, HCAK, MO15, STK1, CDKN7, p39MO15
Tested Applications
ELISA, WB, IHC
Protein ID
4502743
Physical Properties
Liquid

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