CDK8 Antibody

• Background:

  The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

• NCBI Gene ID:

  1024

• Swiss Prot:

  P49336

• Accession Number:

  P49336

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human CDK8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Zebrafish, Mouse, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDK8

• NCBI Official Name:

  Cyclin-dependent kinase 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Seo, J.O., et al. Oncol. Rep. 24 (1) :285-291 (2010)

• Background Reference 02:

  Tsutsui, T., et al. Seikagaku 82 (3) :191-199 (2010)

• Background Reference 03:

  Chattopadhyay, I., et al. Mutat. Res. 696 (2) :130-138 (2010)

• Background Reference 04:

  Donner, A.J., et al. Nat. Struct. Mol. Biol. 17 (2) :194-201 (2010)

• Other Product Names:

  Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, CDK8

• Tested Applications:

  WB, Flow

• Protein ID:

  1345718

• Physical Properties:

  Liquid