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CDK8 Antibody

CAT: 0223-56-151Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-151Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
NCBI Gene ID
1024
Swiss Prot
P49336
Accession Number
P49336
Host
Rabbit
Reactivity
Human
Immunogen
This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human CDK8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish, Mouse, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Symbol
CDK8
NCBI Official Name
Cyclin-dependent kinase 8
NCBI Organism
Homo sapiens
Background Reference 01
Seo, J.O., et al. Oncol. Rep. 24 (1) :285-291 (2010)
Background Reference 02
Tsutsui, T., et al. Seikagaku 82 (3) :191-199 (2010)
Background Reference 03
Chattopadhyay, I., et al. Mutat. Res. 696 (2) :130-138 (2010)
Background Reference 04
Donner, A.J., et al. Nat. Struct. Mol. Biol. 17 (2) :194-201 (2010)
Other Product Names
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, CDK8
Tested Applications
WB, Flow
Protein ID
1345718
Physical Properties
Liquid

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