CDK2 Antibody

CAT: 0223-62-964Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-964Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) . Its activity is also regulated by its protein phosphorylation.
NCBI Gene ID
1017
Swiss Prot
P24941
Accession Number
P24941
Host
Rabbit
Reactivity
Human
Immunogen
This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the C-terminal region of human CDK2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Hamster, Mouse, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Symbol
CDK2
NCBI Official Name
Cyclin-dependent kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Moshinsky, D.J., et al., Biochem. Biophys. Res. Commun. 310 (3) :1026-1031 (2003) .
Background Reference 02
Chow, J.P., et al., J. Biol. Chem. 278 (42) :40815-40828 (2003) .
Background Reference 03
O'Nions, J., et al., Oncogene 22 (46) :7181-7191 (2003) .
Background Reference 04
Yun, J., et al., J. Biol. Chem. 278 (38) :36966-36972 (2003) .
Other Product Names
Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2
Tested Applications
WB, IHC-P, Flow
Protein ID
116051
Physical Properties
Liquid

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