CDK2 Antibody

• Background :

  CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) . Its activity is also regulated by its protein phosphorylation.

• NCBI Gene ID :

  1017

• Swiss Prot :

  P24941

• Accession Number :

  P24941

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the C-terminal region of human CDK2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Hamster, Mouse, Rat, Xenopus

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  34 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CDK2

• NCBI Official Name :

  Cyclin-dependent kinase 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Moshinsky, D.J., et al., Biochem. Biophys. Res. Commun. 310 (3) :1026-1031 (2003) .

• Background Reference 02 :

  Chow, J.P., et al., J. Biol. Chem. 278 (42) :40815-40828 (2003) .

• Background Reference 03 :

  O'Nions, J., et al., Oncogene 22 (46) :7181-7191 (2003) .

• Background Reference 04 :

  Yun, J., et al., J. Biol. Chem. 278 (38) :36966-36972 (2003) .

• Other Product Names :

  Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  116051

• Physical Properties :

  Liquid