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Aromatase Antibody

CAT: 0223-62-799Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-799Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
NCBI Gene ID
1588
Swiss Prot
P11511
Accession Number
P11511
Host
Rabbit
Reactivity
Human
Immunogen
This Aromatase (CYP19A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-253 amino acids from the Central region of human Aromatase (CYP19A1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rb
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CYP19A1
NCBI Official Name
Aromatase
NCBI Organism
Homo sapiens
Background Reference 01
Ikeda, S., Am. J. Gastroenterol. 103 (6), 1476-1487 (2008)
Background Reference 02
Dos Santos, (er) DNA Cell Biol. (2008) In press
Background Reference 03
Nelson, Pharmacogenetics 14 (1), 1-18 (2004)
Other Product Names
Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
Tested Applications
WB
Protein ID
117293
Physical Properties
Liquid

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