MAPK1 Antibody

• Background:

  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

• NCBI Gene ID:

  5594

• Swiss Prot:

  P28482

• Accession Number:

  P28482

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the Central region of human MAPK1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Xenopus, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAPK1

• NCBI Official Name:

  Mitogen-activated protein kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Munshi, H.G., et al., J. Biol. Chem. 279 (37) :39042-39050 (2004) .

• Background Reference 02:

  Mukherjee, S., et al., Infect. Immun. 72 (9) :5274-5282 (2004) .

• Background Reference 03:

  Lou, Y., et al., Biochem. Biophys. Res. Commun. 321 (2) :495-501 (2004) .

• Background Reference 04:

  Mitsushima, M., et al., J. Biol. Chem. 279 (33) :34570-34577 (2004) .

• Other Product Names:

  Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, MAPK1, ERK2, PRKM1, PRKM2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  119554

• Physical Properties:

  Liquid