PANK2 Antibody

• Background :

  Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS) . PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP) .

• NCBI Gene ID :

  80025

• Swiss Prot :

  Q9BZ23

• Accession Number :

  Q9BZ23

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human PANK2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Obesity, Neuroscience, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  63 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  PANK2

• NCBI Official Name :

  Pantothenate kinase 2, mitochondrial

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Neurology 58: 1673-1674, 2002.

• Background Reference 02 :

  Hum. Molec. Genet. 12: 321-327, 2003.

• Background Reference 03 :

  Neurology 61: 1423-1426, 2003.

• Background Reference 04 :

  Neurology 64: 1810-1812, 2005.

• Other Product Names :

  Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2, PANK2, C20orf48

• Tested Applications :

  WB

• Protein ID :

  118572682

• Physical Properties :

  Liquid