PAN2 Antibody

• Background:

  This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly (A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  9924

• Swiss Prot:

  Q504Q3

• Accession Number:

  Q504Q3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PAN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 860-888 amino acids from the C-terminal region of human PAN2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  135 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PAN2

• NCBI Official Name:

  PAB-dependent poly (A) -specific ribonuclease subunit PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care (2010) In press :

• Background Reference 02:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 03:

  Funakoshi, Y., et al. Genes Dev. 21 (23) :3135-3148 (2007)

• Background Reference 04:

  Ezzeddine, N., et al. Mol. Cell. Biol. 27 (22) :7791-7801 (2007)

• Other Product Names:

  PAB-dependent poly (A) -specific ribonuclease subunit PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}, hPan2, 31134 {ECO:0000255|HAMAP-Rule:MF_03182}, Inactive ubiquitin carboxyl-terminal hydrolase 52 {ECO:0000255|HAMAP-Rule:MF_03182}, PAB1P-dependent poly (A) -nuclease {ECO:0000255|HAMAP-Rule:MF_03182}, PAN deadenylation complex catalytic subunit 2 {ECO:0000255|HAMAP-Rule:MF_03182}, PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}, KIAA0710, USP52

• Tested Applications:

  WB

• Protein ID:

  296439280

• Physical Properties:

  Liquid