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KIST Antibody

CAT: 0223-62-628Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-628Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KIST, a member of the Ser/Thr protein kinase family, is a pyruvate kinase that catalyzes formation of phosphoenolpyruvate from pyruvate and ATP. A role for the primarily nuclear KIST protein in mediation of cellular metabolism has been postulated based on the interaction identified with thyroid hormone. KIST is widely expressed, with highest abundance in skeletal muscle, kidney, placenta and peripheral blood leukocytes. Upon serum stimulation, KIST phosphorylates CDKN1B/p27Kip1, thereby regulating the subcellular location of CDKN1B and cell cycle progression in the G1 phase. KIST, which contains one RNA recognition motif domain, has been proposed to partipate in trafficking and processing of RNA. KIST binds to Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells.
NCBI Gene ID
127933
Swiss Prot
Q8TAS1
Accession Number
Q8TAS1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-295 amino acids from the C-terminal region of human KIST (KIS) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
UHMK1
NCBI Official Name
Serine/threonine-protein kinase Kist
NCBI Organism
Homo sapiens
Background Reference 01
Bieche, I., et al., Brain Res. Mol. Brain Res. 114 (1) :55-64 (2003) .
Background Reference 02
Boehm, M., et al., EMBO J. 21 (13) :3390-3401 (2002) .
Background Reference 03
Caldwell, B.D., et al., J. Biol. Chem. 274 (49) :34646-34656 (1999) .
Other Product Names
Serine/threonine-protein kinase Kist, Kinase interacting with stathmin, PAM COOH-terminal interactor protein 2, P-CIP2, U2AF homology motif kinase 1, UHMK1, KIS, KIST
Tested Applications
WB
Protein ID
24211880
Physical Properties
Liquid

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