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PKC nu Antibody

CAT: 0223-62-599Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-599Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC nu is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
NCBI Gene ID
23683
Swiss Prot
O94806
Accession Number
O94806
Host
Rabbit
Reactivity
Human
Immunogen
This PKC-nu antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-384 amino acids from human PKC-nu.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
100 kDa
Fragment
Rabbit Ig
Symbol
PRKD3
NCBI Official Name
Serine/threonine-protein kinase D3
NCBI Organism
Homo sapiens
Background Reference 01
Yeaman, C., et al., Nat. Cell Biol. 6 (2) :106-112 (2004) .
Background Reference 02
Rey, O., et al., J. Biol. Chem. 278 (26) :23773-23785 (2003) .
Background Reference 03
Matthews, S.A., et al., J. Biol. Chem. 278 (11) :9086-9091 (2003) .
Background Reference 04
Bennasser, Y., et al., Virology 303 (1) :174-180 (2002) .
Other Product Names
Serine/threonine-protein kinase D3, Protein kinase C nu type, Protein kinase EPK2, nPKC-nu, PRKD3, EPK2, PRKCN
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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