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PKC epsilon Antibody

CAT: 0223-62-593Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-593Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC epsilon is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS) -mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
NCBI Gene ID
5581
Swiss Prot
Q02156
Accession Number
Q02156
Host
Rabbit
Reactivity
Human
Immunogen
This PKC epsilon antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the N-terminal region of human PKC epsilon.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
84 kDa
Fragment
Rabbit Ig
Symbol
PRKCE
NCBI Official Name
Protein kinase C epsilon type
NCBI Organism
Homo sapiens
Background Reference 01
Gray, M.O., et al., J. Biol. Chem. 279 (5) :3596-3604 (2004) .
Background Reference 02
Ling, M., et al., Exp. Cell Res. 292 (1) :135-150 (2004) .
Background Reference 03
McJilton, M.A., et al., Oncogene 22 (39) :7958-7968 (2003) .
Background Reference 04
Robu, V.G., et al., J. Biol. Chem. 278 (48) :48154-48161 (2003) .
Other Product Names
Protein kinase C epsilon type, nPKC-epsilon, PRKCE, PKCE
Tested Applications
WB, IHC-P
Protein ID
400135
Physical Properties
Liquid

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