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PKC gamma Antibody

CAT: 0223-62-595Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-595Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14) .
NCBI Gene ID
5582
Swiss Prot
P05129
Accession Number
P05129
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PKC gamma antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the C-terminal region of human PKC gamma.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
78 kDa
Fragment
Rabbit Ig
Symbol
PRKCG
NCBI Official Name
Protein kinase C gamma type
NCBI Organism
Homo sapiens
Background Reference 01
Uchino, M., et al., J. Biol. Chem. 279 (3) :2254-2261 (2004) .
Background Reference 02
Van de Warrenburg, B.P., et al., Neurology 61 (12) :1760-1765 (2003) .
Background Reference 03
Yabe, I., et al., Arch. Neurol. 60 (12) :1749-1751 (2003) .
Background Reference 04
Ananthanarayanan, B., et al., J. Biol. Chem. 278 (47) :46886-46894 (2003) .
Other Product Names
Protein kinase C gamma type, PKC-gamma, PRKCG, PKCG
Tested Applications
WB, IHC-P
Protein ID
462455
Physical Properties
Liquid

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