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PKC alpha Antibody

CAT: 0223-62-590Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-590Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC alpha is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca (2+) handling in myocytes.
NCBI Gene ID
5578
Swiss Prot
P17252
Accession Number
P17252
Host
Rabbit
Reactivity
Human
Immunogen
This PKC alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-329 amino acids from the C-terminal region of human PKC alpha.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
77 kDa
Fragment
Rabbit Ig
Symbol
PRKCA
NCBI Official Name
Protein kinase C alpha type
NCBI Organism
Homo sapiens
Background Reference 01
Rabinovitz, I., et al., Mol. Cell. Biol. 24 (10) :4351-4360 (2004) .
Background Reference 02
Gong, N., et al., Proc. Natl. Acad. Sci. U.S.A. 101 (17) :6490-6495 (2004) .
Background Reference 03
Hermoso, M., et al., J. Biol. Chem. 279 (17) :17681-17689 (2004) .
Background Reference 04
Zemskov, E.A., et al., Neuroreport 14 (11) :1435-1438 (2003) .
Other Product Names
Protein kinase C alpha type, PKC-A, PKC-alpha, PRKCA, PKCA, PRKACA
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
317373571
Physical Properties
Liquid

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