Products for Research Use Only
RegisterLogin

PKC beta1/2 Antibody

CAT: 0223-62-591Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-62-591Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.
NCBI Gene ID
5579
Swiss Prot
P05771
Accession Number
P05771
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PKC beta1/2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-334 amino acids from the Central region of human PKC beta1/2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
77 kDa
Fragment
Rabbit Ig
Symbol
PRKCB
NCBI Official Name
Protein kinase C beta type
NCBI Organism
Homo sapiens
Background Reference 01
Chen, D., et al., J. Biol. Chem. 279 (6) :4829-4839 (2004) .
Background Reference 02
Hug, B.A., et al., J. Biol. Chem. 279 (2) :825-830 (2004) .
Background Reference 03
Wu, H., et al., Biochem. Biophys. Res. Commun. 311 (4) :948-953 (2003) .
Background Reference 04
Becker, K.P., et al., J. Biol. Chem. 278 (52) :52747-52754 (2003) .
Other Product Names
Protein kinase C beta type, PKC-B, PKC-beta, PRKCB, PKCB, PRKCB1
Tested Applications
WB, IHC-P
Protein ID
20141488
Physical Properties
Liquid

Related Products

CatalogName
62-602PKC zeta Antibody
62-601PKC theta Antibody
62-596PKC iota Antibody
62-600PKC nu Antibody
62-597PKC mu Antibody
62-594PKC eta Antibody
62-599PKC nu Antibody
62-593PKC epsilon Antibody
62-592PKC delta Antibody
62-590PKC alpha Antibody

Alternative Products

CatalogName
E45R05834G-4PKC beta1/2 Antibody (Center)
GTR18963738PKC beta1/2 Antibody Blocking peptide
APR05834G-01PKC beta1/2 Antibody (Center) [APR05834G]
MBS8584285-01Beta1-tubulin Antibody
MBS9519488-01Centaurin-beta1 Antibody
MBS9503749-01AMPK beta1 Antibody
MBS9503555-01Integrin beta1 Antibody
MBS9418725-01Defensin beta1 Antibody
ANT-35401-100ugGABAR, Beta1 Antibody
E312273TGF beta1 Antibody

Popular Products