CLC4 Antibody

• Background:

  The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.

• NCBI Gene ID:

  1183

• Swiss Prot:

  P51793

• Accession Number:

  P51793

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CLC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  85 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CLCN4

• NCBI Official Name:

  H (+) /Cl (-) exchange transporter 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wang, T., et al., Gastroenterology 126 (4) :1157-1166 (2004) .

• Background Reference 02:

  Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31 (3) :657-666 (1999) .

• Background Reference 03:

  Dinulos, M.B., et al., Genomics 35 (1) :244-247 (1996) .

• Background Reference 04:

  Schnur, R.E., et al., Hum. Genet. 95 (5) :594-595 (1995) .

• Other Product Names:

  H (+) /Cl (-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  20141247

• Physical Properties:

  Liquid